Endogenous catecholamine participates in the action of interleukin-2 on the isolated rat heart / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 51-54, 2005.
Article
em Zh
| WPRIM
| ID: wpr-287103
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To explore whether endogenous catecholamine participates in the effect of interleukin-2 on the isolated heart.</p><p><b>METHODS</b>The number of premature ventricular contraction (PVC), left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure(LVEDP), heart rate (HR) and coronary flow(CF)were recorded in isolated Langendorff perfused rat hearts.</p><p><b>RESULTS</b>(1) 50 U/ml IL-2 increased the PVC number, LVDP LVEDP, HR and CF. (2) Pretreatment of reserpine or propranolol abolished the cardiac effect of IL-2 at 50 U/ml, while pretreatment with phentolamine did not change the effect of IL-2. (3) 200 U/ml IL-2 increased the number of PVC,but did not increase LVDP, LVEDP, HR and CF. (4) After pretreatment of reserpine or propranolol, IL-2 failed to increase the number of PVC, but caused decrease of LVDP, HR and CF, and elevation of LVEDP.</p><p><b>CONCLUSION</b>Endogenous catecholamine mediates the arrhythmogenic, positively chronotropic and inotropic effects of IL-2. IL-2 at 200 U/ml inhibits the cardiac function in the isolated rat heart.</p>
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Índice:
WPRIM
Assunto principal:
Farmacologia
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Fisiologia
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Técnicas In Vitro
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Catecolaminas
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Interleucina-2
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Ratos Sprague-Dawley
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Coração
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Contração Miocárdica
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2005
Tipo de documento:
Article