Effect of the Yifuning soft gelatin capsules on estrogen receptor and nitric oxide levels in ovariectomized rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of the Yifuning soft gelatin capsules(YFN)on estrogen receptor (ER) and nitric oxide (NO) levels in ovariectomized rats.</p><p><b>METHOD</b>Fifty female mature sprague-dawley rats were randomly divided into 5 groups normal control; model control; diethylstilbestrol tablets (DT); YFN (high dose and low dose). After 4 weeks' treatment, the serum E2 levels were detected by radioimmunoassay. The estrogen receptor (ER) levels of uterus and artery were detected with method of radioligand binding assay of receptor (RBAR). The uterus pathologic changes were investigated with light microscope. NO and NOS levels of the artery and the uterus index were detected too.</p><p><b>RESULT</b>YFN can obviously improve serum E2, increase index and ER of uterus (P < 0.01 or P < 0.05), and ameliorate the uterus' pathologic changes in OVX rats. It also can increase the artery' ER, NO and NOS levels.</p><p><b>CONCLUSION</b>YFN can cure the climacteric syndrome and prevent the cardiovascular disease after post-menopause.</p>