Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 340-344, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-287394
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the mitochondrial DNA region np16181-16193 variations with type 2 diabetes mellitus (T2DM).</p><p><b>METHODS</b>Blood samples of 199 unrelated T2DM patients and 205 normal controls were collected to detect the mitochondrial DNA region np16181-16193 variations by PCR and sequencing, and to analyze the association of the variations with the major clinical symptoms.</p><p><b>RESULTS</b>The mitochondrial DNA np16181-16193 region is a hypervariable area, with several polymorphisms. Four types of np16181-16193 region variations were found only in T2DM. The 1-hour postprandial blood glucose (P1BG) in the T2DM individuals with np16181-16193 region variations was significantly higher than those without variations (P<0.05), while there was no significant difference in other biochemical parameters (P>0.05).</p><p><b>CONCLUSION</b>The mitochondrial DNA np16181-16193 variations could not be regarded as a risk factor for T2DM.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
DNA Mitocondrial
/
Análise Mutacional de DNA
/
Análise de Sequência de DNA
/
Predisposição Genética para Doença
/
Regiões Determinantes de Complementaridade
/
Diabetes Mellitus Tipo 2
/
Genoma Mitocondrial
/
Genética
Tipo de estudo:
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2009
Tipo de documento:
Artigo
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