The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 95-97, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-287445
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.</p><p><b>METHODS</b>Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.</p><p><b>RESULTS</b>Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.</p><p><b>CONCLUSION</b>The SRY gene is key in sex determination and development, yet there might be other important genes involved.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fenótipo
/
Aberrações dos Cromossomos Sexuais
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Transtornos dos Cromossomos Sexuais
/
Genes sry
/
Genética
/
Genitália Masculina
Limite:
Adulto
/
Criança, pré-escolar
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2009
Tipo de documento:
Artigo
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