Hypnotic effect of Chinese materia medica Cynanchum chinese in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1774-1776, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-287897
ABSTRACT
<p><b>OBJECTIVE</b>To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.</p><p><b>METHOD</b>The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.</p><p><b>RESULT</b>the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.</p><p><b>CONCLUSION</b>The extract compounds from C. chinese showed inhibitional effect on CNS.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pentobarbital
/
Farmacologia
/
Fisiologia
/
Plantas Medicinais
/
Sono
/
Medicamentos de Ervas Chinesas
/
Água
/
Distribuição Aleatória
/
Sistema Nervoso Central
/
Química
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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