Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 855-860, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-287972
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of mitochondrial DNA 5178 C/A (Mt5178) polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes mellitus (T2DM) among ethnic Han Chinese through a case-control study.</p><p><b>METHODS</b>The Mt5178C/A polymorphism was determined by sequencing 1103 T2DM patients and 791 healthy controls. Logistic regression analysis was conducted to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm the results, a meta-analysis was conducted based on published literature on the association of Mt5178 variant with T2DM.</p><p><b>RESULTS</b>No significant association was found between the Mt5178C/A variant and T2DM either by our study or the meta-analysis which included eight published studies. Nevertheless, it was found that the T2DM patients with 5178C genotype were at a higher risk for nephropathy complication (OR=1.49, 95%CI 1.005-2.197, P<0.05) and at significantly lower risk for hypertension complication (OR=0.744, 95%CI 0.556-0.996, P<0.05) compared with those carrying a 5178A genotype.</p><p><b>CONCLUSION</b>No association was found between the Mt5178C/A polymorphism of mitochondrial ND2 gene with the increased risk of T2DM. However, the polymorphism may affect the development of nephropathy and hypertension complications among T2DM patients.</p>
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triglicerídeos
/
Sangue
/
Glicemia
/
DNA Mitocondrial
/
Razão de Chances
/
Química
/
Metanálise como Assunto
/
Colesterol
/
Jejum
/
Análise de Sequência de DNA
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Revisões Sistemáticas Avaliadas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2015
Tipo de documento:
Artigo
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