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Effects of Intravenous Magnesium Sulfate on the Prevention of Pain Following Injection of Microemulsion Propofol
Soonchunhyang Medical Science ; : 70-74, 2015.
Artigo em Inglês | WPRIM | ID: wpr-28820
ABSTRACT

OBJECTIVE:

The aim of this study was to investigate the effects of intravenous magnesium sulfate on the prevention of pain during the injection of microemulsion propofol. Magnesium is a known calcium channel blocker and a physiological N-methyl-D-aspartate receptor antagonist.

METHODS:

American Society of Anesthesiologists I and II adults (n=114) undergoing general anesthesia for surgery were randomly assigned into two groups (n=57 per group). This study was designed in prospective and double-blind manner. Patients in the LM group (n=57) received pretreatment with 2% lidocaine (40 mg) and magnesium sulfate 10 mg/kg, while patients in group L (n=57) received pretreatment with 2% lidocaine (40 mg) and normal saline (2 mL) accompanied by venous occlusion. Induction with microemulsion propofol (Aquafol) 2 mg/kg was accomplished following the release of venous occlusion. Pain intensity was assessed on a four-point scale according to patient movement (grade 0, no movement; grade 1, movement in wrist only; grade 2, movement in the upper arm & shoulder of injected arm; grade 3, generalized movement). Systolic blood pressure, diastolic blood pressure, and heart rate were evaluated.

RESULTS:

A significant difference in pain intensity following injection of microemulsion propofol between the groups was found (P<0.05). In addition, the incidence of hypertension after injection was lower in the LM group than in the L group (P<0.05).

CONCLUSION:

The combination of magnesium and lidocaine are effective in attenuating the pain induced by microemulsion propofol injection when compared with lidocaine alone.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Braço / Ombro / Punho / Pressão Sanguínea / Canais de Cálcio / Propofol / Incidência / Estudos Prospectivos / N-Metilaspartato / Frequência Cardíaca Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Soonchunhyang Medical Science Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Braço / Ombro / Punho / Pressão Sanguínea / Canais de Cálcio / Propofol / Incidência / Estudos Prospectivos / N-Metilaspartato / Frequência Cardíaca Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Soonchunhyang Medical Science Ano de publicação: 2015 Tipo de documento: Artigo