Study on the correlation between single nucleotide polymorphism of monoamine oxidase A gene and anger regulation / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the correlation between single nucleotide polymorphism (SNP) of monoamine oxidase A gene (MAOA) and anger regulation.</p><p><b>METHODS</b>Enrolled were healthy students from some college, including 225 of the high trait anger and 221 of the low trait anger. Subjects were recruited referring to the state-trait anger expression inventory 2 (STAXI-2) and their blood sampled. The DNA was extracted using phenol-chloroform method, 4 tag SNPs of MAOA (rs5906957, rs2235186, rs1181275, and rs5905613) were genotyped by PCR-based ligase detection reaction (PCR-LDR). The scores for trait anger expression inventory and the scores for trait anger expression control at the 4 tag SNPs of MAOA in the different sexes groups of the high and the low trait anger were statistical analyzed.</p><p><b>RESULTS</b>There was statistical difference in anger control score of locus rs2235186 of MAOA gene group (P = 0.037). There was no significant difference in anger expression or anger control score of different genotypes of the other three tag SNPs (P > 0.05).</p><p><b>CONCLUSION</b>MAOA gene tag SNP rs2235186 was correlated with anger control traits of healthy female college students of the low trait anger in China.</p>