Extended transsphenoidal operation for giant and invasive pituitary adenomas / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the possibility of extended transsphenoidal approach for removing the giant and invasive pituitary adenomas.</p><p><b>METHODS</b>The clinical data of 64 cases with giant and invasive pituitary adenoma treated by extended transsphenoidal approach were studied retrospectively.</p><p><b>RESULTS</b>Among 64 patients, 51 had total resection and 13 had subtotal resection. 26 patients occurred transient diabetes insipidus, 5 patients with transient cerebrospinal rhinorrhoea and 1 patient occurred acute hypopituitarism postoperatively. There were no death or intracranial infection. After operation, 8 patients get radiotherapy, 6 patients receive medicine treatment. Postoperative follow-up period was 3 months to 6 years. No regrowth or recurrence was seen.</p><p><b>CONCLUSION</b>The extended transsphenoidal approach has been proved to a safe and effective method to remove the giant and invasive pituitary adenomas. Patients who got subtotal resection need be close followed-up and receive radiotherapy or medicine treatment it necessary.</p>