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Study about target-network of anti-cerebral infarction neuropathy based on theory of neurovascular unit and network pharmacology / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 138-141, 2012.
Artigo em Chinês | WPRIM | ID: wpr-288684
ABSTRACT
<p><b>OBJECTIVE</b>Potention drug-targets on anti-neuropathy of stroke were summarized, and it will provide materials for developing innovation components traditional Chinese medicine on anti-cerebral infarction neuropathy.</p><p><b>METHOD</b>This article had done a series of researching work about neurovascular unit which includes three kinds of cells neuron, gliacyte,brain microvascular endothelial cell, then signal mechanism of cell death or apoptosis of each section of stroke neuropathy was analysised by the historical documents.</p><p><b>RESULT</b>There are five important pathways inflammatory factor-MMPs pathway- Caspases, Ca2+ -mitochondrial pathway-Caspases, Ca2+ -Phospholipase-PI-3K/AK pathway, Ca2+ -radical-MAPK pathway, Ca2+ -NO-protease pathway, among all the nodes, Caspases, Ca2+, NO were the most important ones.</p><p><b>CONCLUSION</b>Developing the multi-mechanism and multilevel of traditional chinese medicine under the guidance of the theories of network pharmacology and neurovascular unit will play an important role in studying the key links of signal-network of stroke neuropathy.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Polineuropatias / Transdução de Sinais / Infarto Cerebral / Cálcio / Sistemas de Liberação de Medicamentos / Fosfatidilinositol 3-Quinases / Caspases / Metaloproteinases da Matriz / Sistema de Sinalização das MAP Quinases Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Polineuropatias / Transdução de Sinais / Infarto Cerebral / Cálcio / Sistemas de Liberação de Medicamentos / Fosfatidilinositol 3-Quinases / Caspases / Metaloproteinases da Matriz / Sistema de Sinalização das MAP Quinases Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Artigo