Prediction of network drug target based on improved model of bipartite graph valuation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 125-129, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-288687
ABSTRACT
Network pharmacology, as a new developmental direction of drug discovery, was generating attention of more and more researchers. The key problem in drug discovery was how to identify the new interactions between drugs and target proteins. Prediction of new interaction was made to find potential targets based on the predicting model constructed by the known drug-protein interactions. According to the deficiencies of existing predicting algorithm based bipartite graph, a supervised learning integration method of bipartite graph was proposed in this paper. Firstly, the bipartite graph network was constructed based on the known interactions between drugs and target proteins. Secondly, the evaluation model for association between drugs and target proteins was created. Thirdly, the model was used to predict the new interactions between drugs and target proteins and confirm the new predicted targets. On the testing dataset, our method performed much better than three other predicting methods. The proposed method integrated chemical space, therapeutic space and genomic space, constructed the interaction network of drugs and target proteins, created the evaluation model and predicted the new interactions with good performance.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Algoritmos
/
Preparações Farmacêuticas
/
Proteínas
/
Sistemas de Liberação de Medicamentos
/
Genômica
/
Mapeamento de Interação de Proteínas
/
Descoberta de Drogas
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Artigo
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