Effects of long-term external use of goupi gao on renal functions and lead accumulation in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 731-734, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-288718
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of long-term external use of Goupi Gao on renal function and lead accumulation in rats.</p><p><b>METHOD</b>Rats were externally administered with Goupi Gao at different doses (7, 3.5 and 1.75 g x kg(-1)) for 90 d. At 45 days and 90 days after administration, the renal indicator, levels of blood urea nitrogen (BU) and creatinine (Cr) in serum, beta2-microglobulin (beta2-MG) and N-acetyl-beta-D-glucosaminidase (NAG) in urine were determined. Lead content in kidneys was detected by atomic absorption spectrometry.</p><p><b>RESULT</b>A 90-day administration with Goupi Gao significantly enhanced the renal indicator, levels of NAG in urine and lead content in renal, when compared with the normal rats. However, the levels of BUN and beta2-MG as well as renal pathology in Goupi Gao treated rats were not obviously changed.</p><p><b>CONCLUSION</b>Consecutive administration of Goupi Gao for 90 days can increase the renal indicator and levels of NAG in urine, enhance the accumulation of lead in renal, but with no effect on excretory function of kidneys and organic changes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Acetilglucosaminidase
/
Espectrofotometria Atômica
/
Urina
/
Sangue
/
Nitrogênio da Ureia Sanguínea
/
Medicamentos de Ervas Chinesas
/
Distribuição Aleatória
/
Microglobulina beta-2
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Artigo
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