Structure and function influence of cochlear after dexamethasone intratympanic application / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 440-443, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-288859
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of the structure and function of cochlear after dexamethasone intratympanic application.</p><p><b>METHODS</b>Forty-five guinea pigs were divided into three groups as normal group, 0.9% sodium chloride injection group and 0.5% dexamethasone group. By using the auditory brainstem response (ABR), the superoxide dismutase (SOD) activity, the nitric oxide (NO) value and cochlear surface preparation technique, the changes of structure and function of cochlear after intratympanic Dexamethasone application has been investigated in this study.</p><p><b>RESULTS</b>There was not significant difference among three groups in ABR thresholds of wave III (F = 0.5, P = 0.5). There was not significant difference among three groups in SOD activity (F = 2.45, P = 0.96). There was not significant difference among three groups in NO value (F = 3.1, P = 0.3). There was not significant difference among three groups in necrotic values of hair cells on the cochlear surface specimens in 15 mm from basal turn (F = 0.93, P = 0.45).</p><p><b>CONCLUSION</b>There is no change of cochlear construction and function after intratympanic Dexamethasone application.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Superóxido Dismutase
/
Dexametasona
/
Administração Tópica
/
Potenciais Evocados Auditivos do Tronco Encefálico
/
Cóclea
/
Orelha Média
/
Cobaias
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2005
Tipo de documento:
Artigo
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