Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model at different stages of inflammation of varied severity.</p><p><b>METHODS</b>The periodontal tissues were immunohistochemically stained by antibody of MMP-2 and MMP-3.</p><p><b>RESULTS</b>MMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodontitis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis.</p><p><b>CONCLUSION</b>The expression of MMP-2 and MMP-3 varies in different stage of periodontitis. MMP-2 and MMP-3 may play an important role in development of periodontitis.</p>