Effects of overdosed fluoride on rat's incisor expression of matrixmetalloproteinase-20 and tissue inhibitors of metalloproteinase-2 / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 199-201, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-288970
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of overdosed fluoride on the expression of MMP-20 and TIMP-2 in rat incisor.</p><p><b>METHODS</b>20 Wistar rats were randomly divided into experiment group and control group. The distilled water was given in control group. 100 mg/L fluoride- was given in experiment group. After 8 weeks treatment, the rats were killed. Immunohistochemical staining was used to observe the expression of MMP-20 and TIMP-2 in rat incisors.</p><p><b>RESULTS</b>Immunohistochemical results demonstrated the presence of MMP-20 and TIMP-2 protein in ameloblasts, odontoblasts, stratum intermedium and the stellate reticulum of rat incisor. The imagination analysis results showed that the expression of MMP-20 was reduesed in experiment group (P<0.01), and the expression of TIMP-2 had no significant difference (P>0.05).</p><p><b>CONCLUSION</b>The overdosed fluoride inhibits the secretion of MMP-20 and leads to the disturbed balance between MMP-20, TIMP-2 in rat incisor, which leads to the delay of the amelogenin removal and the enamel demineralization.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfatos
/
Ratos Wistar
/
Inibidor Tecidual de Metaloproteinase-2
/
Esmalte Dentário
/
Metaloproteases
/
Fluoretos
/
Ameloblastos
/
Incisivo
/
Fluorose Dentária
Limite:
Animais
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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