The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.</p><p><b>METHODS</b>Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.</p><p><b>RESULTS</b>Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).</p><p><b>CONCLUSION</b>Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.</p>