Effects of Jujingwan on nitric oxide and superoxide dismutase in seminal plasma of asthenospermia patients / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the possible action mechanism of Jujingwan on asthenospermia.</p><p><b>METHODS</b>Semen routine analyses and determination of nitric oxide (NO) concentration and superoxide dismutase (SOD) activity in seminal plasma were performed in 34 cases of asthenospermia. The changes of NO concentration and SOD activity before and after the treatment with Jujingwan were observed.</p><p><b>RESULTS</b>Compared with pre-treatment, there was no significant change in NO concentration, and the activity of SOD decreased significantly after the treatment ([95.97 +/- 20.75] microg/L vs [6.14 +/- 19.99] microg/L). There was negative correlation between NO concentration and SOD activity before the treatment (r = -0.246, P < 0.05).</p><p><b>CONCLUSION</b>Jujingwan can significantly improve sperm viability in patients with asthenospermia. However, the excellent effects of Jujingwan are not displayed in the changes of NO concentration and SOD activity.</p>