Effects of ganoderma lucidum spores on cytochrome C and mitochondrial calcium in the testis of NIDDM rats / 中华男科学杂志
National Journal of Andrology
;
(12): 1072-1075, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-289077
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Ganoderma lucidum spores on Cytochrome C (Cyt-C) and mitochondrial calcium in the testis of NIDDM rats.</p><p><b>METHODS</b>Fifty male Wistar rats were divided randomly into three groups model, ganoderma and normal control, the first two groups injected with 2% STZ through vena caudalis, and the last one with half-and-half sodium citrate/citrate buffer solution. Two weeks after normal diet, glucose tolerance tests were performed and the rats with abnormal glucose tolerance from the model and ganoderma groups received high-fat and high-carbohydrate food, the ganoderma group given Ganoderma lucidum spores (250mg/[ kg x d] ) in addition, both for 10 weeks. Glucose tolerance tests were repeated 1 day before the end of the experiment and the rats were castrated and relevant indexes measured.</p><p><b>RESULTS</b>The NIDDM model was successfully constructed. In the model group, the levels of mitochondrial Cyt-C and mitochondrial calcium were significantly lower (P <0. 05) while that of the plasma Cyt-C was significantly higher than in the ganoderma and the control groups.</p><p><b>CONCLUSION</b>Cyt-C and calcium ion are involved in the damage of the testis. Ganoderma lucidum spores can protect the testis of NIDDM rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testículo
/
Distribuição Aleatória
/
Cálcio
/
Ratos Wistar
/
Reishi
/
Citocromos c
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Artigo
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