A study of the expression of hypertrophic scar related cytoskeletal genes during early postburn stage / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 29-31, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-289171
ABSTRACT
<p><b>OBJECTIVE</b>To screen the hypertrophic scar related cytoskeletal genes during early postburn stage, so as to explore their roles in postburn scar contraction.</p><p><b>METHODS</b>cDNA microarray chips containing 4096 human cDNAs were employed to investigate the cytoskeletal gene expression of the scar samples from human postburn hypertrophic scar. Furthermore, the expression of one of the cytoskeletal genes in hypertrophic scar tissue was studied by in situ hybridization.</p><p><b>RESULTS</b>Thirteen up - regulated cytoskeletal genes in 3 early postburn hypertrophic scar samples were identified. Moreover, the cells expressing human tropomyosin TM30 mRNA, one of the up - regulated cytoskeletal genes, were found increased in the early postburn hypertrophic scar samples.</p><p><b>CONCLUSION</b>In this study up - regulated expression of many hypertrophic scar related cytoskeletal genes was found in the scar samples during early postburn stage, and they might be important factors leading to postburn hypertrophic scar formation and contraction.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tropomiosina
/
Citoesqueleto
/
Queimaduras
/
RNA Mensageiro
/
Regulação para Cima
/
Cicatriz Hipertrófica
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2002
Tipo de documento:
Artigo
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