Cyclic nucleotides phosphodiesterase activity in a rat lung model of asthma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 127-130, 2002.
Article
em Zh
| WPRIM
| ID: wpr-289341
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WPRO
ABSTRACT
OBJECTIVE: To assess the change of cGMP-PDE and cAMP-PDE activity in a rat lung model of asthma. METHODS: cGMP-PDE and cAMP-PDE activity were determined by HPLC. RESULTS: Both cAMP-PDE activity and cGMP-PDE activity in the lung tissue of antigen-challenged rats were higher than that from the normal rats (P <0.05). CONCLUSION: In the rat lung model of asthma, cyclic nucleotides phosphodiesterase activity was elevated. This may be significant in the pathogenesis of asthma.
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WPRIM
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2002
Tipo de documento:
Article