Optimization of extraction procedure of tongmai granules by orthogonal design with pharmacodynamic index / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 154-157, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-289409
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the extraction technology for anti-myocardial ischemia active component group in tongmai granules.</p><p><b>METHOD</b>The extracting conditions were optimized by using orthogonal experiment and pharmacodynamic index. Employing puerarin, ferulic acid, tanshinone IIA, and salvianolic acid B as indexes, the effects of ethanol concentration, solvent volume, extraction times and extraction time on the extracting process were investigated.</p><p><b>RESULT</b>The optimum extraction process was adding 8 times amount of 70% alcohol, refluxing and extracting for 3 times, 1.5 h each time.</p><p><b>CONCLUSION</b>This extraction process shows good stability and is available for extracting anti-myocardial ischemia component group in tongmnai granules.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Cromatografia Líquida de Alta Pressão
/
Tecnologia Farmacêutica
/
Ratos Sprague-Dawley
/
Métodos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
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