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Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 100-106, 2015.
Artigo em Chinês | WPRIM | ID: wpr-289458
ABSTRACT
The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application of BM-MSCs in the treatment of acquired AA. An increasingly number of laboratory statistics has demonstrated that the defectiveness of BM-MSCs is more likely to play an important role in the pathogenesis of AA, namely, the apparently different biological characteristics and gene expression profiles, the decreased ability of supporting hematopoiesis as well as self-renewal and differentiation, and the exhaustion of regulating immune response of hematopoietic environment. Those abnormalities continuously prompt AA to become irreversible bone marrow failure along with the imbalanced immunity. With deepening research on MSCs, infusion of MSCs for the primary purpose of recovering hematopoietic microenvironment may become a new approach for the treatment of AA.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Medula Óssea / Ativação Linfocitária / Diferenciação Celular / Citocinas / Linfócitos T Reguladores / Transplante de Células-Tronco Mesenquimais / Proliferação de Células / Alergia e Imunologia Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Medula Óssea / Ativação Linfocitária / Diferenciação Celular / Citocinas / Linfócitos T Reguladores / Transplante de Células-Tronco Mesenquimais / Proliferação de Células / Alergia e Imunologia Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2015 Tipo de documento: Artigo