Effect of smoking on the microRNAs expression in pneumoconiosis patients / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 686-688, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-289828
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of smoking on the microRNAs (miRNAs) expression in pneumoconiosis patients.</p><p><b>METHODS</b>Real-time qPCR was used to measure the expression levels of miR-21, miR-200c, miR-16, miR-204, miR-206, miR-155, let-7g, miR-30b, and miR-192 in 36 non-smoking patients with pneumoconiosis and 38 smoking patients with pneumoconiosis, and the differences in expression levels between the two groups were evaluated by two-independent samples t-test.</p><p><b>RESULTS</b>The expression of miR-192 in serum showed a significant difference between non-smoking and smoking pneumoconiosis patients (P < 0.05), and it decreased gradually in smoking patients with stage I and II pneumoconiosis. In the serum of all pneumoconiosis patients, the expression level of miR-16 was the highest, while the expression level of miR-204 was the lowest.</p><p><b>CONCLUSION</b>Pneumoconiosis patients have differential expression of miRNAs in serum, and smoking has an effect on the miRNAs expression in pneumoconiosis patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumoconiose
/
Fumar
/
Reação em Cadeia da Polimerase
/
MicroRNAs
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2014
Tipo de documento:
Artigo
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