Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 360-363, 2016.
Article
em En
| WPRIM
| ID: wpr-289855
Biblioteca responsável:
WPRO
ABSTRACT
CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.
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Índice:
WPRIM
Assunto principal:
Patologia
/
Fisiologia
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Leucócitos Mononucleares
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Regulação para Baixo
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Transformação Celular Neoplásica
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Quimiocinas
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Proteínas com Domínio MARVEL
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Genética
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Neoplasias
Limite:
Humans
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Male
Idioma:
En
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2016
Tipo de documento:
Article