Bioinformatic and Expression Analysis of Ventricular Septal Defect-associated Long Non-coding RNA TUC40- / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 1-8, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-289915
ABSTRACT
<p><b>OBJECTIVE</b>To explore the potential role of TUC40- in human and mouse embryonic heart development.</p><p><b>METHODS</b>Bioinformatics databases including NCBI,UCSC,and Uniprot and software including Clustal,DNAMAN,and MEGA 6 were used to collect information of TUC40- and uc.40-. The expression profile at key time points of heart development was investigated by strand-specific quantitative real time polymerase chain reaction.</p><p><b>RESULTS</b>Uc.40- was conservative in sequence, genomic location, and transcription factor binding sites across human and mouse. Pbx1/TUC40- showed negative trend during embryonic mouse heart maturation.</p><p><b>CONCLUSIONS</b>Various levels of conservation of uc.40- suggests similar functions of TUC40- in these two species. TUC40- may play its roles in human and mouse embryonic heart development by regulating Pbx1.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biologia Computacional
/
Reação em Cadeia da Polimerase em Tempo Real
/
RNA Longo não Codificante
/
Comunicação Interventricular
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2016
Tipo de documento:
Artigo
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