Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1132-1133, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-289975
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.</p><p><b>METHODS</b>32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.</p><p><b>RESULTS</b>Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.</p><p><b>CONCLUSION</b>Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sangue
/
Linfócitos
/
Doença Crônica
/
Quinase 2 de Receptor Acoplado a Proteína G
/
Genética
/
Insuficiência Cardíaca
/
Metabolismo
/
Metoprolol
Limite:
Idoso
/
Aged80
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS