Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 197-204, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-290153
ABSTRACT
Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and differentiation potential into multiple tissues. Thus, management of the differentiation capacities of MSCs is important for MSC-based regenerative medicine, such as craniofacial bone regeneration, and in new treatments for metabolic bone diseases, such as osteoporosis. In recent years, histone modification has been a growing topic in the field of MSC lineage specification, in which the Su(var)3-9, enhancer-of-zeste, trithorax (SET) domain-containing family and the Jumonji C (JmjC) domain-containing family represent the major histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs), respectively. In this review, we summarize the current understanding of the epigenetic mechanisms by which SET domain-containing KMTs and JmjC domain-containing KDMs balance the osteogenic and adipogenic differentiation of MSCs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Fisiologia
/
Diferenciação Celular
/
Histona-Lisina N-Metiltransferase
/
Linhagem da Célula
/
Proteínas F-Box
/
Epigênese Genética
/
Adipogenia
/
Histona Desmetilases
/
Histona Desmetilases com o Domínio Jumonji
Limite:
Humanos
Idioma:
Inglês
Revista:
International Journal of Oral Science
Ano de publicação:
2015
Tipo de documento:
Artigo
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