The role of microRNAs in bone remodeling / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 131-143, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-290156
ABSTRACT
Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Fisiologia
/
Transcrição Gênica
/
Remodelação Óssea
/
Linhagem da Célula
/
Biologia Celular
/
MicroRNAs
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
International Journal of Oral Science
Ano de publicação:
2015
Tipo de documento:
Artigo
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