Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer / 中华预防医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer.</p><p><b>METHODS</b>Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR.</p><p><b>RESULTS</b>Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39).</p><p><b>CONCLUSION</b>IL8-251-A allele might be associated with higher risk of developing gastric cancer.</p>