Effects of cholesterol ester transfer protein Taq1B polymorphism on response of serum HDL-C to dietary factors in hyperlipidemia patients / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 269-272, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-290274
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the effects of cholesterol ester transfer protein (CETP) Taq1B polymorphism on the response of serum HDL-C to dietary factors in hyperlipidemia patients.</p><p><b>METHODS</b>All 141 hyperlipidemia residents in a community in Shanghai were investigated by a 3-day diet questionnaire. The serum lipids were analyzed, and the polymorphism of CETP gene was detected by PCR-RFLP method. The correlation between dietary factors and serum HDL-C in different genotype was analyzed when considering the effects of sex, age and body mass index.</p><p><b>RESULT</b>The HDL-C of hyperlipidemia patients was affected by dietary factors and CETP gene Taq1B polymorphism. The strength of the correlation between dietary factors and serum HDL-C was different among the genotype groups. The relation was shown closer in B(2)B(2) subjects than in B(1)B(1).</p><p><b>CONCLUSION</b>The Taq1B CETP gene polymorphism should be a strong determinant of HDL-C in hyperlipidemia patients, and might contribute to the heterogeneity in HDL-C response to dietary intervention.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Polimorfismo de Nucleotídeo Único
/
Dieta
/
Suscetibilidade a Doenças
/
Proteínas de Transferência de Ésteres de Colesterol
/
Frequência do Gene
/
Genética
/
Genótipo
/
Hiperlipidemias
/
HDL-Colesterol
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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