Endothelial dysfunction in patients with obstructive sleep apnoea independent of metabolic syndrome
Annals of the Academy of Medicine, Singapore
;
: 461-464, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-290372
ABSTRACT
<p><b>INTRODUCTION</b>Obstructive sleep apnoea syndrome (OSAS), characterised by intermittent hypoxia/re-oxygenation, has been identified as an independent risk factor for cardiovascular diseases and endothelial dysfunction. Our aim was to investigate flow-mediated dilatation (FMD) in patients with obstructive sleep apnoea with and without metabolic syndrome.</p><p><b>MATERIALS AND METHODS</b>Fifty-two subjects with OSAS diagnosed by polysomnography were classified into 2 groups according to the presence and absence of the metabolic syndrome and also according to the severity mild to moderate OSAS group and severe OSAS group. Endothelial function of the brachial artery was evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperaemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate. Spearman correlation and regression analysis were performed.</p><p><b>RESULTS</b>EDD was not significantly different in patients with OSAS and metabolic syndrome as compared with OSAS without metabolic syndrome (4.62 +/- 0.69 versus 4.49 +/- 0.93, P >0.05).</p><p><b>CONCLUSIONS</b>Endothelial dysfunction in OSA may be independent of metabolic syndrome.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Diagnóstico por Imagem
/
Endotélio Vascular
/
Estudos de Casos e Controles
/
Ultrassonografia
/
Apneia Obstrutiva do Sono
/
Síndrome Metabólica
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2009
Tipo de documento:
Artigo
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