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Detection of total and covalently closed circular HBV DNA in liver transplant recipients due to HBV-associated liver diseases / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 594-598, 2015.
Artigo em Chinês | WPRIM | ID: wpr-290394
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the levels of hepatitis B virus (HBV) total DNA and covalently closed circular (ccc) DNA in liver transplant recipients due to HBV-associated liver diseases and detemaine their clinical significance.</p><p><b>METHODS</b>Sixty patients undergoing liver transplantation (LT) due to HBV-associated liver diseases were enrolled for the study. Levels of HBV total and ccc DNA in plasma, liver and PBMCs were measured by RT-PCR.</p><p><b>RESULTS</b>The ratio of malefemale participants was 4812. The mean age was 52.98+/-9.40 years old, and the median duration post-LT was 72 (25-128) months. 59 of the patients had no detectable HBV DNA in plasma.Four patients had detectable levels of total HBV DNA in PBMCs, but no detectable ccc DNA. Five patients had detectable levels of total HBV DNA in liver, and two of those also had detectable levels of ccc DNA. One patients who had detectable HBV DNA in PBMCs suffered HBV recurrence.</p><p><b>CONCLUSION</b>The liver transplant recipients with detectable levels of HBV total and ccc DNA in PBMCs and liver should be considered high risk for HBV recurrence following LT.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / DNA Circular / DNA Viral / Vírus da Hepatite B / Transplante de Fígado / Hepatite B Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hepatology Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / DNA Circular / DNA Viral / Vírus da Hepatite B / Transplante de Fígado / Hepatite B Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hepatology Ano de publicação: 2015 Tipo de documento: Artigo