Effect of HDL and apoAI on PGE2 production by monocyte-derived macrophages / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 270-272, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-290538
ABSTRACT
Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI (apoAI) on production of prostaglandin E2 (PGE2) by human monocyte-derived macrophages was investigated. Macrophages were loaded with acetylated low density lipoprotein followed by incubation with HDL3 or apoAI. PGE2 produced and secreted in culture supernatant was quantified by enzyme immunoassay. HDL3 induced production of PGE2 by macrophages in a time-dependent manner. 24 h after incubation, PGE2 production by HDL3-treated macrophages increased 3.7-fold of that by control cells. ApoAI also induced PGE2 secretion to 2.1-fold, which was significantly less than HDL3. The data indicate that both HDL3 and lipid-free apoAI enhance PGE2 synthesis and secretion by human macrophages and this may further contribute to the protection from atherosclerosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Arteriosclerose
/
Monócitos
/
Dinoprostona
/
Apolipoproteína A-I
/
Meios de Cultivo Condicionados
/
Biologia Celular
/
Lipoproteínas HDL3
/
Lipoproteínas HDL
/
Macrófagos
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Ano de publicação:
2002
Tipo de documento:
Artigo
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