Resistance and treatment strategy of gastrointestinal stromal tumor target therapy / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 309-312, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-290798
ABSTRACT
Gastrointestinal stromal tumor(GIST) originates from interstitial cells of Cajal(ICCs). Tyrosine kinase inhibitors(TKI) such as imatinib and sunitinib, are effective agents besides surgery. However some GIST can become primarily or secondarily resistant to those drugs. The difference in gene mutation types and secondary gene mutation is the main cause. When the GIST is proved to be drug resistance, reasonable personal treatment strategies based on individualized medicine should be made to improve outcomes and quality of life.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperazinas
/
Pirimidinas
/
Pirróis
/
Benzamidas
/
Resistencia a Medicamentos Antineoplásicos
/
Usos Terapêuticos
/
Tumores do Estroma Gastrointestinal
/
Inibidores de Proteínas Quinases
/
Tratamento Farmacológico
/
Mesilato de Imatinib
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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