Isoproterenol-induced activation of MAPK, NFkappaB and JAK/STAT pathway in mouse myocardium / 生理学报
Acta Physiologica Sinica
;
(6): 449-453, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-290945
ABSTRACT
This study was aimed to determine the in vivo signal transduction pathway responsible for isoproterenol (ISO)-induced cardiac hypertrophy or remodeling. Mice were treated with ISO (15 mg/kg body weight) or vehicle by intraperitoneal injection (i.p.). Activation of mitogen-activted protein kinase (MAPK), NF-kappaB and JAK/STAT pathway in the left ventricular myocardium was measured by Western blot analysis. ISO significantly activated MAPK (ERK1/2 and p38) at early phase (5 min); biphasic activation of NF-kappaB was observed in our in vivo study; and ISO caused a delayed STAT3 activation (at 60 to 240 min) in mouse myocardium. Taken together, these results indicate that ISO activates these signal transduction pathways in different time course.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fatores de Tempo
/
Transdução de Sinais
/
NF-kappa B
/
Proteínas Quinases Ativadas por Mitógeno
/
Fator de Transcrição STAT3
/
Janus Quinase 1
/
Coração
/
Isoproterenol
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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