Human gastric tissues coexpress two different splicing cholecystokinin-B/gastrin receptors / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 440-443, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-291093
ABSTRACT
This study was conducted to explore whether cholecystokinin-B/gastrin receptor (CCKBRwt) gene and its alternative splicing variant (CCKBRi4sv) are expressed in human gastric carcinomas cell line and tissues, and to find out their relationship with the development and progression of human gastric carcinoma. The mRNA expression levels of CCKBRwt and CCKBRi4sv were detected in 30 human gastric carcinomas and normal tissues adjacent to cancer, 10 gastritis specimens, 2 autopsied normal stomach specimens as well as in a gastric carcinoma cell line SGC-7901 cells. The results revealed that the transcripts of CCKBRwt and CCKBRi4sv were observed in all of the human gastric specimens tested, but only CCKBRwt was expressed in gastric cancer cell line SGC-7901 cells. The expression levels of the two receptors were not correlated with the differentiation and metastases of gastric cancers. From the results, we infer that human gastric tissues simultaneously express CCKBRwt and CCKBRi4sv, and CCKBRi4sv may have unknown physiological functions in gastric epithelial cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estômago
/
Neoplasias Gástricas
/
RNA Mensageiro
/
Gastrinas
/
Dados de Sequência Molecular
/
Células Tumorais Cultivadas
/
Sequência de Bases
/
Receptor de Colecistocinina B
/
Células Epiteliais
/
Mucosa Gástrica
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2004
Tipo de documento:
Artigo
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