Preparation of hemoglobin-loaded nanoparticles and safety evaluation in vitro and in vivo / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 584-588, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-291187
ABSTRACT
Hemoglobin-loaded nano-sized particles with oxygen carrying capacity were prepared. All experiments were performed using biodegradable polymer poly (polyepsilon-caprolactone) (PCL) as matrix polymer. Optimized preparation parameters led to nanoparticles with well-defined characteristics such as size <200 nm, P50 27 mmHg and high encapsulation efficiency up to 99.4%. The results of in vitro and vivo studies suggested that Hb-loaded particles did not activate complements. After the nanoparticles suspension was injected into the mice via tail vein, the particles did not cause significant changes in total platelet counts. Apparently, the hemoglobin-loaded nanoparticles can serve as a potential candidate in substitution for red cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Poliésteres
/
Materiais Biocompatíveis
/
Substitutos Sanguíneos
/
Teste de Materiais
/
Hemoglobinas
/
Química
/
Nanopartículas
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2008
Tipo de documento:
Artigo
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