Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3473-3478, 2013.
Article
em Zh
| WPRIM
| ID: wpr-291343
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.</p><p><b>METHOD</b>The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.</p><p><b>RESULT</b>The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.572 5f-20. 729 (R2 = 0.974 5); F(pseudoephedrine) = 1.237f-0.147 6 (R2 = 0.959 5).</p><p><b>CONCLUSION</b>The results suggested that there was fine correlation between the absorption percentage in vivo and the accumulative release percentage in vitro of Chuanping sustained release tablets.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Solubilidade
/
Comprimidos
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Preparações de Ação Retardada
/
Efedrina
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Article