A meta-analysis of cohort studies on the association between diabetes and the risk of primary liver cancer / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 711-716, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-291510
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between diabetes and risks of primary liver cancer.</p><p><b>METHODS</b>A Meta-analysis was performed to estimate the pooled relative risk (RR) to evaluate the relationship between diabetes and the risk of primary liver cancer from cohort studies, which were identified by searching in Medline, Chinese CNKI and Wanfang databases from January 1989 to February 2010. A total of 28 publications were found according to this method. Adjusted RRs and their corresponding 95% confidence intervals (95%CI) were calculated by using the fixed-effect and random-effect model in our analysis. We also conducted a number of sub-groups analysis stratified by some important variables, such as source, gender, region and quality of study.</p><p><b>RESULTS</b>A total of 3800 cases of liver cancer and 3 672 248 study subjects from 14 prospective cohorts were included in our analysis. The pooled RR of primary liver cancer was 3.33 (95%CI 1.82 - 6.10) for persons with diabetes when compared to subjects without diabetes. The results showed a significant association between diabetes and the risk of primary liver cancer based on these cohort studies. Subgroup analysis indicated that the pooled RRs for diabetes were 3.76 (95%CI 1.69 - 8.38) in the population-based cohorts and 2.41 (1.34 - 4.32) in the hospital-based cohorts. In terms of the sex groups, the pooled RRs for diabetes were 2.32 (95%CI 1.70 - 3.17) for males and 1.63 (95%CI 1.08 - 2.47) for females, respectively.</p><p><b>CONCLUSION</b>As one of independent risk factors, diabetes was associated with an increased risk of primary liver cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
China
/
Epidemiologia
/
Fatores de Risco
/
Estudos de Coortes
/
Complicações do Diabetes
/
Diabetes Mellitus
/
Neoplasias Hepáticas
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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