Confirmation of 17 rare HLA alleles and prediction of their haplotypes / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 518-521, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-291737
ABSTRACT
<p><b>OBJECTIVE</b>To confirm 17 rare HLA alleles detected during routine HLA typing and deduce their haplotypes.</p><p><b>METHODS</b>Bi-allelic sequence-based typing and Luminex DNA PCR-SSOP assay were applied for the initial or repeat HLA typing, respectively. The rare HLA alleles were confirmed with mono-allelic sequence-based typing. Predicted haplotypes of the rare alleles were inferred based on the frequencies of HLA alleles and haplotypes in Han population.</p><p><b>RESULTS</b>The authenticity of the total 17 rare HLA alleles was proven, and 18 predicted haplotypes associated with the rare alleles were recognized. A*1112 and DRB1*1319 were detected twice among unrelated individuals.</p><p><b>CONCLUSION</b>Study of rare HLA alleles and predicted haplotype can provide useful information for donor searching and transplantation, and enrich polymorphisms of HLA in this population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Antígenos HLA-A
/
Antígenos HLA-B
/
Povo Asiático
/
Alelos
/
Etnologia
/
Cadeias HLA-DRB1
/
Frequência do Gene
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2014
Tipo de documento:
Artigo
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