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Effects of tea polyphenols and tea pigments on telomerase activity of HepG2 cells / 中华预防医学杂志
Zhonghua Yu Fang Yi Xue Za Zhi ; (12): 159-161, 2004.
Article em Zh | WPRIM | ID: wpr-291799
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study is to investigate the effect of tea polyphenols and tea pigments on telomerase activity of human liver cancer cell line, HepG2 cells.</p><p><b>METHODS</b>TRAP-PCR-ELISA was applied to investigate the telomerase activity.</p><p><b>RESULTS</b>Telomerase was positive in tea polyphenols treated groups, tea pigments treated groups and blank control group. Telomerase activities (A(450 approximately 690) values) were 1.56 and 1.46 in 50 mg/L and 100 mg/L tea polyphenols-treated groups, 1.55 and 1.49 in 50 mg/L and 100 mg/L tea pigments-treated groups, respectively. The results showed that telomerase activity was significantly inhibited by tea polyphenols and tea pigments treatment as compared with the blank control group (A(450 approximately 690) = 2.11).</p><p><b>CONCLUSIONS</b>Tea polyphenols and tea pigments could significantly inhibit telomerase activity of HepG2 cells, and telomerase activity may be a useful biomarker for cancer chemoprevention.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Farmacologia / Fenóis / Pigmentos Biológicos / Chá / Flavonoides / Células Tumorais Cultivadas / Biomarcadores Tumorais / Química / Carcinoma Hepatocelular Limite: Humans Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Ano de publicação: 2004 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Farmacologia / Fenóis / Pigmentos Biológicos / Chá / Flavonoides / Células Tumorais Cultivadas / Biomarcadores Tumorais / Química / Carcinoma Hepatocelular Limite: Humans Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Ano de publicação: 2004 Tipo de documento: Article