Effects of tea polyphenols and tea pigments on telomerase activity of HepG2 cells / 中华预防医学杂志
Zhonghua Yu Fang Yi Xue Za Zhi
; (12): 159-161, 2004.
Article
em Zh
| WPRIM
| ID: wpr-291799
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study is to investigate the effect of tea polyphenols and tea pigments on telomerase activity of human liver cancer cell line, HepG2 cells.</p><p><b>METHODS</b>TRAP-PCR-ELISA was applied to investigate the telomerase activity.</p><p><b>RESULTS</b>Telomerase was positive in tea polyphenols treated groups, tea pigments treated groups and blank control group. Telomerase activities (A(450 approximately 690) values) were 1.56 and 1.46 in 50 mg/L and 100 mg/L tea polyphenols-treated groups, 1.55 and 1.49 in 50 mg/L and 100 mg/L tea pigments-treated groups, respectively. The results showed that telomerase activity was significantly inhibited by tea polyphenols and tea pigments treatment as compared with the blank control group (A(450 approximately 690) = 2.11).</p><p><b>CONCLUSIONS</b>Tea polyphenols and tea pigments could significantly inhibit telomerase activity of HepG2 cells, and telomerase activity may be a useful biomarker for cancer chemoprevention.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Fenóis
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Pigmentos Biológicos
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Chá
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Flavonoides
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Células Tumorais Cultivadas
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Biomarcadores Tumorais
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Química
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Carcinoma Hepatocelular
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Yu Fang Yi Xue Za Zhi
Ano de publicação:
2004
Tipo de documento:
Article