Study on the absorption, distribution and excretion of 3-chloro-1,2-propandiol in rats / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 426-428, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-291833
ABSTRACT
<p><b>OBJECTIVE</b>To explore the absorption, distribution and excretion of 3-Chloro-1,2-propandiol (3-MCPD) in healthy male SD rats after oral administration.</p><p><b>METHODS</b>3-MCPD was administrated with a single oral dosage of 75 mg/kg BW to each rat. Samples of blood, tissues (including liver, kidney, brain and testicle) and excreta were then collected, and analyzed by the GC-MS method to determine 3-MCPD concentrations. The reported value is the mean value of three rats.</p><p><b>RESULTS</b>At 2 h after the administration, 3-MCPD concentrations in blood, testicle and kidney were (67.46 +/- 7.72), (78.37 +/- 5.15) and (56.21 +/- 3.64) microg/g, respectively. At 24 h, however, the corresponding values changed to (1.07 +/- 0.97) microg/g, (49.43 +/- 28.18) microg/g and (11.41 +/- 2.55) microg/g. During the 24-hour period, 9.74 +/- 3.05% of the given parent compound was excreted in urine, whereas 0.56 +/- 0.22% and 0.28 +/- 0.03% were excreted in feces and bile, respectively, which implies that kidney is a major organ for excretion 3-MCPD.</p><p><b>CONCLUSIONS</b>3-MCPD was quickly absorbed through the alimentary tract and quickly distributed into a number of tissues, and then accumulated in the target organs, especially in the testicle. The excretion of the parent compound was largely through the kidney. It was inferred that 3-MCPD was mainly metabolized in the liver.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testículo
/
Encéfalo
/
Farmacocinética
/
Distribuição Tecidual
/
Esterilizantes Químicos
/
Administração Oral
/
Monitoramento de Medicamentos
/
Ratos Sprague-Dawley
/
Absorção
/
Alfa-Cloridrina
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2003
Tipo de documento:
Artigo
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