Influence of endothelial cells on the proliferation of scar-derived fibroblast in hypertropic scar tissue / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 338-340, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-292066
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of the endothelial cells on the scar-derived fibroblasts in the hypertropic scar tissue.</p><p><b>METHODS</b>The endothelial cell from the human umbilical vein was cultured and its supernatant was then collected. Thereafter, it was mixed with the pre-cultured scar-derived fibroblasts from the hypertropic scar tissue. The fibroblasts were analyzed with a flow cytometer in a MTT-assay method to evaluate the cell proliferation and its division cycle.</p><p><b>RESULTS</b>The endothelial cells were significantly increasing the scar-derived fibroblast proliferation (P < 0.05), compared with the control. The proportion of the fibroblasts in the S-stage of cell cycle was also quite high.</p><p><b>CONCLUSION</b>The endothelial cells may secrete some active products, which may enhance the proliferation of the scar-derived fibroblasts and stimulate the fibroblasts into the S-stage of cell generation cycle.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Endotélio Vascular
/
Ciclo Celular
/
Divisão Celular
/
Linhagem Celular
/
Células Cultivadas
/
Química
/
Meios de Cultivo Condicionados
/
Cicatriz Hipertrófica
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2002
Tipo de documento:
Artigo
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