Experimental study on the inflammatory and immune responses of xenogenic acellular dermal matrix transplantation combined with thin split-thickness skin autograft / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 266-268, 2002.
Article
em Zh
| WPRIM
| ID: wpr-292086
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the dynamic process of the inflammatory response and the profile of Th1/Th2 cytokines after xenogenic acellular dermal matrix (ADM) transplantation with thin split-thickness skin autograft overlay.</p><p><b>METHODS</b>SD rats were used in the study. In the control group, thin split-thickness skin autograft (STSG) was transplanted in the full-thickness skin defect of the SD rats; in the experimental group, the xenogenic acellular dermal matrix combined with thin split-thickness skin autograft was transplanted. The inflammatory response was examined histologically and Th1/Th2 cytokine mRNA expression in skin grafts was determined by reverse transcription-polymerase chain reaction.</p><p><b>RESULTS</b>Inflammatory reaction was induced by ADM at the early stage of transplantation and decreased gradually. Th2 cytokine mRNA expression was higher in the ADM group than that of the control group whereas the Th1 cytokine mRNA expression was undetected in both groups.</p><p><b>CONCLUSION</b>Xenogenic acellular dermal matrix is immunogenic. The increased expression of Th2 cytokines may be related to the humoral immune responses and the absence of ADM graft rejection.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Suínos
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Transplante
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Transplante Autólogo
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Transplante Heterólogo
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RNA Mensageiro
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Expressão Gênica
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Citocinas
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Interferon gama
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Interleucina-2
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Transplante de Pele
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2002
Tipo de documento:
Article