Experimental studies on cranial defect repair with marrow stromal osteoblast-cancellous bone matrix compound artificial bone / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 226-228, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-292091
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility of using marrow stromal osteoblast-cancellous bone matrix compound artificial bone (MCCAB) as tissue-engineered bone, the osteogenesis of MCCAB in the cranial defect was observed in the experiment.</p><p><b>METHODS</b>The in vitro cultivated and induced marrow stromal cells of adult New Zealand rabbits were seeded into the alginate-cancellous bone matrix to form MCCAB. The MCCAB was then implanted into the cranial defect for 4 to 8 weeks. The cancellous bone matrix (CBM) alone or the marrow stromal osteoblasts (MSOs) alone was implanted as the control. The effectiveness of bone formation was assessed by histological and roentgenographic analysis.</p><p><b>RESULTS</b>The osteogenesis of MCCAB was better than CBM or MSOs and superior to the blank group.</p><p><b>CONCLUSION</b>MCCAB can effectively repair cranial defect. It could be used clinically to restore large bone defects.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Fisiologia
/
Crânio
/
Anormalidades Congênitas
/
Matriz Óssea
/
Células da Medula Óssea
/
Células Cultivadas
/
Estudos de Viabilidade
/
Células Estromais
/
Biologia Celular
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2002
Tipo de documento:
Artigo
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