Experimental study on the toxic effects of hydrophilic polyacrylamide gel / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the safety of Hydrophilic polyacrylamide gel (HPAG) through an animal experiment.</p><p><b>METHODS</b>After HPAG was injected underneath the skin of SD rats, tissue specimens were taken for general and histological examinations. The cytotoxicity was evaluated by agar coverage and MTT method.</p><p><b>RESULTS</b>It was determined that the cytotoxicity was over level-two. The toxicity to kidney was obvious. The local histological reaction was slight and a thin fibrous membrane was formed around HPAG, which became stiff gradually. The shape and location of the injected HPAG was not stable. The HPAG could not be drawn out completely.</p><p><b>CONCLUSION</b>HPAG has obvious cytotoxicity and is not a suitable material as soft tissue implant for the bad shape and texture.</p>