Effects of microfilaments on the expression of collagenases and tissue inhibitor of metalloproteinases-1 in fibroblasts / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 163-164, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-292124
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roles of microfilaments in the expression of collagenase and TIMP-1 in normal and hypertrophic scar.</p><p><b>METHODS</b>Cell culture and Northern blot hybridization methods were used in this study.</p><p><b>RESULTS</b>After the disruption of microfilaments with cytochalasin B, mRNA contents of collagenase and TIMP-1 both increased significantly in normal and hypertrophic scar fibroblasts.</p><p><b>CONCLUSION</b>The result suggest that the microfilament cytoskeleton may regulate the synthesis and degradation of ECM, which may be a mechanism of gene regulation during wound healing.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Cicatrização
/
Citoesqueleto de Actina
/
RNA Mensageiro
/
Células Cultivadas
/
Colagenases
/
Inibidor Tecidual de Metaloproteinase-1
/
Fibroblastos
/
Genética
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2002
Tipo de documento:
Artigo
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