Progress in using Newcastle disease virus for tumor therapy: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1031-1036, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-292175
ABSTRACT
Naturally existing Newcastle disease virus (NDV) can specifically execute oncolytic ability in clinical studies. Reports from clinical trials using NDV as oncolytic agents showed promise and warrant results in cancer therapy. In recent years, reverse genetics technology has been used widely in the studies of NDV virology. More recently, the technology was applied to optimize the oncolytic efficacy of NDV, for instance, modification of the F gene, and expression of GM-CSF, IFN-gamma, IL-2 or TNF-alpha. NDV is widely investigated in cancer therapy and will definitely offer a prosperous future for clinical cancer therapeutics. We reviewed the developments of cancer therapy by recombinant NDV using reverse genetics technology, as well as our own experience in this domain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Recombinação Genética
/
Terapêutica
/
Vírus da Doença de Newcastle
/
Vírus Oncolíticos
/
Terapia Viral Oncolítica
/
Genética
/
Métodos
/
Neoplasias
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2010
Tipo de documento:
Artigo
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