Aging reduces contents of endogenous CO, cAMP and cGMP in rat penile tissues / 中华男科学杂志
National Journal of Andrology
;
(12): 122-125, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-292413
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship of aging with the changes of endogenous carbon monoxide (CO), cGMP and cAMP contents in the penile tissues of rats.</p><p><b>METHODS</b>Twenty-four male rats were equally divided into an 8-month, a 16-month and a 24-month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry.</p><p><b>RESULTS</b>The contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups (P < 0.01).</p><p><b>CONCLUSION</b>Aging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pênis
/
Fisiologia
/
Envelhecimento
/
Monóxido de Carbono
/
Ratos Wistar
/
AMP Cíclico
/
GMP Cíclico
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2009
Tipo de documento:
Artigo
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