Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3058-3060, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-292754
ABSTRACT
<p><b>BACKGROUND</b>Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis.</p><p><b>METHODS</b>Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients.</p><p><b>RESULTS</b>The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity.</p><p><b>CONCLUSION</b>sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Sangue
/
Ensaio de Imunoadsorção Enzimática
/
Receptores de Superfície Celular
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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